Arthritis Rheumatol:正电子发射断层扫描作为大血管炎的影像学生物标志物

2017-11-21 xiangting MedSci原创

FDG-PET提供有关血管炎症的信息,这些信息与LVV的临床评估是相辅相成的。

这项研究旨在评估18F-氟脱氧葡萄糖(FDG)正电子发射断层扫描(PET)在前瞻性大血管炎(LVV)患者队列和疾病对照中的临床应用价值。

纳入多发性大动脉炎(TAK)和巨细胞动脉炎(GCA)患者,对照组由高脂血症、与LVV相似的疾病和健康对照组成。参与者进行临床评估和FDG-PET显像,LVV患者每六个月进行一次连续成像。计算FDG-PET将临床活动性LVV与疾病对照和临床缓解区别开的解读特征。使用基于整体动脉FDG摄取的定性总结评分(PETVAS)来研究PET活动性与临床特征之间的关联并预测未来复发。

115名参与者进行了170次FDG-PET扫描(LVV = 56;对照组= 59)。FDG-PET将临床活动性LVV和疾病对照区别开的灵敏度为85%(95%CI:69-94%)和特异度为83%(95%CI:71-91%)。大多数LVV临床缓解的患者FDG-PET扫描被解读为活动性血管炎(71例中41例,58%)。临床疾病活动状态,疾病持续时间,体重指数和糖皮质激素使用与PET扫描活动性独立相关。中位随访15个月期间,临床缓解期接受PET扫描的患者中,PETVAS较高的临床复发比低的患者(45%vs.11%,p = 0.03)更常见。

FDG-PET提供有关血管炎症的信息,这些信息与LVV的临床评估是相辅相成的。临床缓解期间FDG-PET扫描活动性与未来的临床复发相关。

原始出处:

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    2018-08-17 kkunny
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    2017-11-23 zhaojie88
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