Biomed Res Int:含硼生物活性玻璃对聚己内酯成骨和血管生成的刺激作用

2019-04-25 不详 网络

聚己内酯(PCL)由于其成本效率,高韧性和良好的加工性而引起了骨再生的极大关注。然而,纯PCL的相对低的弹性模量,疏水性和不充分的生物活性限制了其更广泛的骨再生应用。本研究中,研究人员探究了添加含硼生物活性玻璃(B-BG)材料对PCL聚合物力学性能和生物学性能的影响,研究了不同的B-BG含量(0,10,20,30和40wt%),以评估B-BG/PCL复合材料在骨再生中的潜在应用。结果表明,与纯PC

聚己内酯(PCL)由于其成本效率,高韧性和良好的加工性而引起了骨再生的极大关注。然而,纯PCL的相对低的弹性模量,疏水性和不充分的生物活性限制了其更广泛的骨再生应用。

本研究中,研究人员探究了添加含硼生物活性玻璃(B-BG)材料对PCL聚合物力学性能和生物学性能的影响,研究了不同的B-BG含量(0,10,20,30和40wt%),以评估B-BG/PCL复合材料在骨再生中的潜在应用。

结果表明,与纯PCL聚合物相比,B-BG / PCL复合材料具有更好的拉伸强度,人体中性pH值和快速降解。此外,与纯PCL聚合物相比,B-BG的掺入可以增强大鼠骨髓基质细胞(rBMSC)的增殖,成骨分化和血管生成因子表达。重要的是,B-BG还促进了人脐静脉内皮细胞(HUVEC)的血管生成分化。这些增强效果具有B-BG含量的浓度依赖性,而30 wt%的B-BG/PCL复合物获得最大的刺激效果。

因此,30 wt%的B-BG/PCL复合材料在骨重建领域具有潜在的应用。

原始出处:

Xia L, Ma W, et al., Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study. Biomed Res Int. 2019 Mar 18;2019:8961409. doi: 10.1155/2019/8961409. eCollection 2019.

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    2019-11-10 sunylz
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    2019-04-27 zhaojie88
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