J Gastroenterology:糖尿病与胰腺脂肪堆积之间的关系

2018-10-04 MedSci MedSci原创

一些横断面研究报道了胰腺脂肪堆积和葡萄糖代谢障碍之间的关系,然而,最近的纵向研究表明,基线胰腺脂肪增加不会导致糖尿病的发生。因此,本项研究旨在研究基线前驱糖尿病与胰腺脂肪积累之间的关联。

背景及目的
一些横断面研究报道了胰腺脂肪堆积和葡萄糖代谢障碍之间的关系,然而,最近的纵向研究表明,基线胰腺脂肪增加不会导致糖尿病的发生。因此,本项研究旨在研究基线前驱糖尿病与胰腺脂肪积累之间的关联。

方法
研究人员回顾性分析了在2008年至2015年期间通过(CT)进行健康检查的198名非糖尿病患者,CT间期≥5年,被列为前驱糖尿病有48名,非前驱糖尿有150名。前驱糖尿病定义为空腹血糖100-125mg / dl或血红蛋白A1c 5.7-6.4%。使用组织学验证的方法评估胰腺脂肪,以测量CT上胰腺和脾脏衰减(P-S)之间的差异。随访期间胰腺脂肪积累测量为P-S的变化。多元线性回归用于评估基线前驱糖尿病与未来胰腺脂肪积累之间的关联。

结果
随访期间胰腺脂肪平均积累为0.30(SD,5.8)Hounsfield。在单变量分析中,基线前驱糖尿病与未来的胰腺脂肪积累相关(β= 3.73; 95%CI 1.91-5.55;P<0.001)。这种关联在多变量分析中仍然具有统计学意义(β= 3.14; 95%CI 1.25-5.03;P= 0.001)。

结论
前驱糖尿病是胰腺脂肪堆积的危险因素。胰腺脂肪可能是葡萄糖代谢障碍的一种表现。

原始出处:

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    2018-11-03 许安
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    2018-10-05 飛歌

    学习了很不错

    0

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    2018-10-05 明月清辉

    谢谢分享,学习了

    0

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    2018-10-05 misszhang

    谢谢MedSci提供最新的资讯

    0