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NAT GENET ：肥胖基因或是黑色素瘤的风险因素

2013-03-06 佚名 科学网

肥胖基因黑色素瘤皮肤癌
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　　一项新研究证实与肥胖和暴饮暴食最密切相关的基因，也可能会增加患恶性黑色素瘤的风险，黑色素瘤是皮肤癌中最致命的一种类型，相关研究发表在Nature Genetics杂志上。 　　英国利兹大学的癌症研究中心科学家发现，FTO基因（通常称为内含子8）的DNA内存在特定变异体的人可能患黑色素瘤的风险更大。FTO基因（内含子1）不同部位的突变体是已知的肥胖和暴饮暴食最重要的遗传危险因素。

　　一项新研究证实与肥胖和暴饮暴食最密切相关的基因，也可能会增加患恶性黑色素瘤的风险，黑色素瘤是皮肤癌中最致命的一种类型，相关研究发表在Nature Genetics杂志上。

　　英国利兹大学的癌症研究中心科学家发现，FTO基因（通常称为内含子8）的DNA内存在特定变异体的人可能患黑色素瘤的风险更大。FTO基因（内含子1）不同部位的突变体是已知的肥胖和暴饮暴食最重要的遗传危险因素。

　　这些变异体与身体质量指数（BMI）相关，高BMI会增加各种疾病包括2型糖尿病，肾脏病，子宫（子宫内膜）癌的风险。但这项研究是首次揭示FTO基因也会影响黑色素瘤的发病。以往研究中并未发现黑色素瘤与肥胖和BMI相关。这项最新研究结果表明，FTO比以前认为的有一个更广泛的作用，参与调控各种不同疾病。

　　研究人员共检测了13,000多名黑色素瘤患者和来自世界各地的近60,000健康者的样本。英国利兹大学癌症研究中心科学家Mark Iles博士在研究报告中说：这是我们第一次发现肥胖基因与黑色素瘤风险相关。这也带来一个问题，该基因是否在更多疾病中发挥作用吗？

　　科学家们试图了解FTO基因是如何发挥作用的，但到目前为止只研究了其对代谢和食欲的作用，因此要想足够了解这样一个有趣的基因是远远不够的。

　　这项新研究或许会带来一个新的研究热点：肥胖与皮肤癌的相关性。恶性黑色素瘤是第五大最常见的癌症，每年在英国大约有12,800新发病例，每年约2200人死亡。Julie Sharp博士表示：如果进一步研究证实FTO基因对黑色素瘤作用，可能对开发新的药物来治疗黑色素瘤提供新的机遇。

与黑色素瘤相关的拓展阅读：


We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 × 10−12, per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanoma-susceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.

    

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    2013-03-11 canlab

    #NET#

    0

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    2013-12-20 江川靖瑶

    #Genet#

    0

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    2013-04-02 liye789132251

    #Nat#

    0

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    2013-11-26 cy0324

    #Gene#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1733627, encodeId=e7af1e33627af, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Mar 11 03:28:00 CST 2013, time=2013-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685887, encodeId=f797168588e41, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Fri Dec 20 06:28:00 CST 2013, time=2013-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879442, encodeId=f56d18e944239, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Apr 02 21:28:00 CST 2013, time=2013-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048502, encodeId=eec62048502df, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 26 17:28:00 CST 2013, time=2013-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040876, encodeId=0e3f20408e6f4, content=<a href='/topic/show?id=46de819020f' target=_blank style='color:#2F92EE;'>#肥胖基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81902, encryptionId=46de819020f, topicName=肥胖基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Mon Sep 30 15:28:00 CST 2013, time=2013-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680219, encodeId=68d1168021950, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Wed Apr 17 03:28:00 CST 2013, time=2013-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558636, encodeId=f1511558636a5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Mar 08 04:28:00 CST 2013, time=2013-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564645, encodeId=818a1564645b5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Mar 08 04:28:00 CST 2013, time=2013-03-08, status=1, ipAttribution=)]
    2013-09-30 xuyong523

    #肥胖基因#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1733627, encodeId=e7af1e33627af, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Mar 11 03:28:00 CST 2013, time=2013-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685887, encodeId=f797168588e41, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Fri Dec 20 06:28:00 CST 2013, time=2013-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879442, encodeId=f56d18e944239, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Apr 02 21:28:00 CST 2013, time=2013-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048502, encodeId=eec62048502df, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 26 17:28:00 CST 2013, time=2013-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040876, encodeId=0e3f20408e6f4, content=<a href='/topic/show?id=46de819020f' target=_blank style='color:#2F92EE;'>#肥胖基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81902, encryptionId=46de819020f, topicName=肥胖基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Mon Sep 30 15:28:00 CST 2013, time=2013-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680219, encodeId=68d1168021950, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Wed Apr 17 03:28:00 CST 2013, time=2013-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558636, encodeId=f1511558636a5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Mar 08 04:28:00 CST 2013, time=2013-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564645, encodeId=818a1564645b5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Mar 08 04:28:00 CST 2013, time=2013-03-08, status=1, ipAttribution=)]
    2013-04-17 sunylz

    #色素#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1733627, encodeId=e7af1e33627af, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Mar 11 03:28:00 CST 2013, time=2013-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685887, encodeId=f797168588e41, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Fri Dec 20 06:28:00 CST 2013, time=2013-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879442, encodeId=f56d18e944239, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Apr 02 21:28:00 CST 2013, time=2013-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048502, encodeId=eec62048502df, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 26 17:28:00 CST 2013, time=2013-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040876, encodeId=0e3f20408e6f4, content=<a href='/topic/show?id=46de819020f' target=_blank style='color:#2F92EE;'>#肥胖基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81902, encryptionId=46de819020f, topicName=肥胖基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Mon Sep 30 15:28:00 CST 2013, time=2013-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680219, encodeId=68d1168021950, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Wed Apr 17 03:28:00 CST 2013, time=2013-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558636, encodeId=f1511558636a5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Mar 08 04:28:00 CST 2013, time=2013-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564645, encodeId=818a1564645b5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Mar 08 04:28:00 CST 2013, time=2013-03-08, status=1, ipAttribution=)]
    2013-03-08 cqlidoudou

    #黑色素#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1733627, encodeId=e7af1e33627af, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Mar 11 03:28:00 CST 2013, time=2013-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685887, encodeId=f797168588e41, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Fri Dec 20 06:28:00 CST 2013, time=2013-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879442, encodeId=f56d18e944239, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Apr 02 21:28:00 CST 2013, time=2013-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048502, encodeId=eec62048502df, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Tue Nov 26 17:28:00 CST 2013, time=2013-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2040876, encodeId=0e3f20408e6f4, content=<a href='/topic/show?id=46de819020f' target=_blank style='color:#2F92EE;'>#肥胖基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81902, encryptionId=46de819020f, topicName=肥胖基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Mon Sep 30 15:28:00 CST 2013, time=2013-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680219, encodeId=68d1168021950, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Wed Apr 17 03:28:00 CST 2013, time=2013-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558636, encodeId=f1511558636a5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Mar 08 04:28:00 CST 2013, time=2013-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564645, encodeId=818a1564645b5, content=<a href='/topic/show?id=e27610332666' target=_blank style='color:#2F92EE;'>#黑色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103326, encryptionId=e27610332666, topicName=黑色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=150614999302, createdName=cqlidoudou, createdTime=Fri Mar 08 04:28:00 CST 2013, time=2013-03-08, status=1, ipAttribution=)]
    2013-03-08 cqlidoudou

    #黑色素#

    0