Diabetes:抗衰老基因为糖尿病治疗带来新希望

2015-09-10 佚名生物谷

近日，来自美国俄克拉荷马大学的华人科学家在国际学术期刊diabetes上发表了一项最新研究进展，他们发现抗衰老基因Klotho能够抑制β细胞凋亡，而异常的细胞凋亡是造成1型糖尿病发病过程中合成胰岛素的β细胞死亡的主要原因。因此这项研究对于1型糖尿病治疗具有重要提示意义。在这项研究中，研究人员检测到最近发现的抗衰老基因Klotho基因在胰腺β细胞中也有表达。非常有趣的是，Klotho基因发生单染色

近日，来自美国俄克拉荷马大学的华人科学家在国际学术期刊diabetes上发表了一项最新研究进展，他们发现抗衰老基因Klotho能够抑制β细胞凋亡，而异常的细胞凋亡是造成1型糖尿病发病过程中合成胰岛素的β细胞死亡的主要原因。因此这项研究对于1型糖尿病治疗具有重要提示意义。

在这项研究中，研究人员检测到最近发现的抗衰老基因Klotho基因在胰腺β细胞中也有表达。非常有趣的是，Klotho基因发生单染色体缺失会加重STZ诱导的糖尿病模型（一种1型糖尿病模型）出现高血糖症，葡萄糖不耐受，胰岛内储存的胰岛素减少，β细胞凋亡增加等症状。而在β细胞内特异性表达Klotho基因可以减弱β细胞的凋亡，并阻止STZ诱导的1型糖尿病发生。

研究人员对其中的机制进行了研究，他们利用培养的MIN6 β细胞发现Klotho会促进细胞黏附到胶原IV，增加FAK和Akt的磷酸化并抑制caspase 3的剪切，这表明Klotho能够通过消除STZ以及TNF a诱导的对FAK和Akt磷酸化的抑制作用，激活整合素β1-FAK/Akt信号途径以抑制caspase 3的功能剪切，进而阻止β细胞发生凋亡。

研究人员还利用自身免疫性1型糖尿病动物模型进行了进一步研究，结果发现在β细胞内特异性表达mKL可以改善葡萄糖耐受性，减缓β细胞凋亡，并增强β细胞内胰岛素的储存以及血浆中的胰岛素水平。

综上所述，这项研究发现抗衰老基因Klotho可以通过激活整合素β1-FAK/Akt信号途径抑制β细胞凋亡，对于1型糖尿病治疗具有重要提示意义。

原文出处：

Yi Lin and Zhongjie Sun,Anti-aging Gene Klotho Attenuates Pancreatic β Cell Apoptosis in Type I Diabetes.Diabetes.2015

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2016-06-09 zhanglin3079

#糖尿病治疗#

63 0
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2016-04-09 木头人513

#Diabetes#

67 0
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2016-06-23 ms9608593228839890

#DIA#

69 0
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2015-09-25 wjcjjian

#抗衰老基因#

69 0
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2016-03-12 珙桐

#新希望#

63 0
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2015-09-10 he408015781

期待进一步的研究

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Diabetes:抗衰老基因为糖尿病治疗带来新希望

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