GetTopicDetailResponse(id=1e513e666a8, topicName=反義寡核苷酸藥物, introduction=反義寡核苷酸藥物, content=null, image=null, comments=2, allHits=1906, url=https://h5.medsci.cn/topic?id=37666, type=0, isShow=1, status=1, isAdmin=null, adminId=1, adminEncryptionId=1eae1, adminName=小M, createdBy=null, createdName=, createdAvatar=, createdTime=Fri May 29 21:19:53 CST 2020, time=2020-05-29, bannerImg=https://img.medsci.cn/202167/1623032167418_5160405.png, bannerImgH5=https://img.medsci.cn/202167/1623032167418_5160405.png, likes=0, followStatus=false, moduleDTOList=null, tagId=88917, tagList=[TagDto(tagId=88917, tagName=反義寡核苷酸藥物)], ipAttribution=, topicAdmin=1, lengthMark=0)
[GetTopicListResponse(id=2090074, encodeId=c74020900e48b, content=該公司在研<a href='/topic/show?id=1e513e666a8' target=_blank style='color:#2F92EE;'>#反義寡核苷酸藥物#</a>ION449（AZD8233）能顯著降低<a href='/topic/show?id=bef6102602a9' target=_blank style='color:#2F92EE;'>#高膽固醇血癥#</a>患者的<a href='/topic/show?id=ada32619472' target=_blank style='color:#2F92EE;'>#低密度脂蛋白膽固醇#</a>（LDL-C）水平，與安慰劑相比，每月皮下注射60mg ION449治療的患者在28周后，<a href='/topic/show?id=593c10e5975' target=_blank style='color:#2F92EE;'>#LDL-C#</a>水平降低了62.3%。雖然降低LDL-C很多，但是與目前已上市的產(chǎn)品相比，并沒有顯示出太多的優(yōu)勢，這是不再開發(fā)的主要原因，并不代表它沒有效！！
這種就是良性<a href='/topic/show?id=65c858648d2' target=_blank style='color:#2F92EE;'>#新藥研發(fā)#</a>狀態(tài)，不象國內(nèi)，只要有效就大家一起上，導致越來越卷！, objectTitle=PCSK9反義療法治療高膽固醇血癥療效未達預期，阿斯利康終止推向III期, objectType=article, longId=740742, objectId=ff9be4074222, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/images/20220915/074d7627c7dc42dc8ed783e69f3a1092.jpg, objectUrl=/article/show_article.do?id=ff9be4074222, replyNumber=0, likeNumber=242, createdTime=2022-09-24, rootId=0, userName=小小醫(yī)者, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=ff9be4074222, moduleTitle=PCSK9反義療法治療高膽固醇血癥療效未達預期，阿斯利康終止推向III期, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=ff9be4074222)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=882460, encodeId=fd3d88246095, content=<a href='/topic/show?id=1e513e666a8' target=_blank style='color:#2F92EE;'>#反義寡核苷酸藥物#</a>GSK’836 (<a href='/topic/show?id=a368103860f9' target=_blank style='color:#2F92EE;'>#GSK3228836#</a>)對乙肝患者實現(xiàn)功能治愈，這是極強的！不過，不知道它對cccDNA降解的作用如何？
如果能搞定cccDNA，那是真正搞定乙肝了, objectTitle=4周可實現(xiàn)“功能性治愈”！GSK反義寡核苷酸療法乙肝IIa期研究取得積極結(jié)果, objectType=article, longId=200199, objectId=df16200199bb, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/102373157-95011716.1910x1000.jpg, objectUrl=/article/show_article.do?id=df16200199bb, replyNumber=0, likeNumber=149, createdTime=2020-09-03, rootId=0, userName=1381abdab4m, userId=f0f41699279, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=df16200199bb, moduleTitle=4周可實現(xiàn)“功能性治愈”！GSK反義寡核苷酸療法乙肝IIa期研究取得積極結(jié)果, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=df16200199bb)], followStatus=false, userIsMember=false, type=1, lengthMark=0)]
梅斯話題小助手
2020-05-29
