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#基因程序# 腦腫瘤治療領(lǐng)域正面臨一個(gè)令人困惑的謎題:為何在其他癌癥中屢建奇功的免疫治療,對(duì)惡性膠質(zhì)瘤卻頻頻失效?2月26日發(fā)表于《Nature》的研究“Programs, origins and immunomodulatory functions of myeloid cells in glioma”給出了**性答案——研究人員發(fā)現(xiàn),膠質(zhì)瘤微環(huán)境中潛藏著一群“雙面間諜”:占據(jù)腫瘤半壁江山的髓系細(xì)胞,竟攜帶四套截然不同的基因程序,在促癌與抗癌之間反復(fù)切換身份。這些細(xì)胞既可能釋放炎癥因子喚醒免疫系統(tǒng),又能通過(guò)清道夫受體吞噬抗癌信號(hào),甚至將常用激素藥物轉(zhuǎn)化為免疫抑制的“幫兇”。