GetTopicDetailResponse(id=4ed86115639, topicName=機(jī)會(huì)性感染, introduction=機(jī)會(huì)性感染, content=null, image=null, comments=2, allHits=1611, url=https://h5.medsci.cn/topic?id=61156, type=1, isShow=1, status=1, isAdmin=null, adminId=1, adminEncryptionId=1eae1, adminName=小M, createdBy=null, createdName=, createdAvatar=, createdTime=Fri May 29 21:19:53 CST 2020, time=2020-05-29, bannerImg=https://img.medsci.cn/202167/1623032167418_5160405.png, bannerImgH5=https://img.medsci.cn/202167/1623032167418_5160405.png, likes=0, followStatus=false, moduleDTOList=null, tagId=58721, tagList=[TagDto(tagId=58721, tagName=機(jī)會(huì)性感染)], ipAttribution=, topicAdmin=1, lengthMark=0)
[GetTopicListResponse(id=2120732, encodeId=3a7c2120e324c, content=這項(xiàng)研究工作通過分離<a href='/topic/show?id=ab181056e1da' target=_blank style='color:#2F92EE;'>#雌二醇降解菌#</a>，發(fā)現(xiàn)了腸道菌Klebsiella aerogenes（<a href='/topic/show?id=c4751056e25c' target=_blank style='color:#2F92EE;'>#產(chǎn)氣克雷伯氏菌#</a>）表達(dá)的3β-HSD能導(dǎo)致宿主血清<a href='/topic/show?id=60ea98e5030' target=_blank style='color:#2F92EE;'>#雌二醇#</a>降低和<a href='/topic/show?id=0a0b5496306' target=_blank style='color:#2F92EE;'>#抑郁#</a>樣行為。這是極有意思的。腸道細(xì)菌能降低雌激素，竟然還是產(chǎn)氣克雷伯氏菌！
事實(shí)上，去年Science Translational Medicine發(fā)表的一項(xiàng)研究表明，在部分<a href='/topic/show?id=b0bc81566c8' target=_blank style='color:#2F92EE;'>#腸易激綜合征#</a>（IBS）患者中，<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#腸道菌群#</a>是<a href='/topic/show?id=a830e7734a0' target=_blank style='color:#2F92EE;'>#組胺#</a>的重要來源，特定的產(chǎn)氣克雷伯菌則是主要“嫌犯”。
意味著產(chǎn)氣克雷伯菌可能扮演很多角色，既可能是IBS的誘因之一，也可能是誘導(dǎo)抑郁，同時(shí)也是<a href='/topic/show?id=4ed86115639' target=_blank style='color:#2F92EE;'>#機(jī)會(huì)性感染#</a>的重要致病菌。
但是，有矛必有盾，腸道中哪些細(xì)菌扮演有益的角色？<a href='/topic/show?id=5d0ee2249b0' target=_blank style='color:#2F92EE;'>#益生菌#</a>, objectTitle=Cell子刊：武漢大學(xué)李艷/王高華/劉忠純揭示腸道細(xì)菌引起女性抑郁癥的潛在機(jī)理, objectType=article, longId=763473, objectId=575ee634733d, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/doctor-writing-D3K6QME.jpg, objectUrl=/article/show_article.do?id=575ee634733d, replyNumber=0, likeNumber=238, createdTime=2023-03-21, rootId=0, userName=俠膽醫(yī)心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=575ee634733d, moduleTitle=Cell子刊：武漢大學(xué)李艷/王高華/劉忠純揭示腸道細(xì)菌引起女性抑郁癥的潛在機(jī)理, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=575ee634733d)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=1247600, encodeId=ece7124e600a7, content=<a href='/topic/show?id=f5db86812f6' target=_blank style='color:#2F92EE;'>#艾滋病毒#</a>暴露和感染兒童<a href='/topic/show?id=4ed86115639' target=_blank style='color:#2F92EE;'>#機(jī)會(huì)性感染#</a>的預(yù)防和治療指南, objectTitle=2022 HHS 艾滋病毒暴露和感染兒童機(jī)會(huì)性感染的預(yù)防和治療指南, objectType=guider, longId=16593, objectId=b784f1c002395ab0, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/guideline/show_article.do?id=b784f1c002395ab0, replyNumber=0, likeNumber=164, createdTime=2022-09-07, rootId=0, userName=小小醫(yī)者, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=b784f1c002395ab0, moduleTitle=2022 HHS 艾滋病毒暴露和感染兒童機(jī)會(huì)性感染的預(yù)防和治療指南, moduleType=guider, hrefUrl=http://ermita.cn/guideline/show_article.do?id=b784f1c002395ab0)], followStatus=false, userIsMember=false, type=1, lengthMark=0)]
梅斯話題小助手
2020-05-29
