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2020-05-29
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以#替戈拉生#為基礎(chǔ)的一線三聯(lián)療法在#幽門螺桿菌#根除率方面不劣于以#蘭索拉唑#為基礎(chǔ)的三聯(lián)療法,非劣效性為10%。整體而言是相似的,不過,替戈拉生作為新藥,價(jià)格遠(yuǎn)遠(yuǎn)高于傳統(tǒng)的PPIs,因此,至少目前不具有性價(jià)比。
或者說,傳統(tǒng)PPIs的抑酸作用在根除幽門螺桿菌中,已達(dá)#天花板效應(yīng)#,再高的抑酸也不能增強(qiáng)效果了,更重要的還是看抗生素的作用,因此,三聯(lián)中抗生素的更新,以后可能會(huì)變得更為關(guān)鍵!畢竟#阿莫西林#,#克拉霉素#,慶大霉素,多少年都沒有變過了。