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#肺高壓#MMP-8 是 PAH 發(fā)病過程中肺血管系統(tǒng)中上調(diào)的新型保護(hù)因子。MMP-8 通過改變 PASMC 中的基質(zhì)組成和破壞整合素-β3/FAK 和 YAP/TAZ 依賴的機(jī)械信號(hào)傳導(dǎo)來對(duì)抗病理機(jī)械生物反饋。
