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#胃食管交界處腺癌# 對(duì)于人表皮生長(zhǎng)因子受體2 (HER2)陰性、局部晚期不可切除或轉(zhuǎn)移性胃或胃食管交界處(mG/GEJ)腺癌患者，迫切需要一線治療方案。Claudin-18亞型2 (CLDN18.2)在正常胃細(xì)胞中表達(dá)，在惡性G/GEJ腺癌細(xì)胞中維持。
2023年7月31日，中山大學(xué)徐瑞華團(tuán)隊(duì)在Nature Medicine在線發(fā)表題為“Zolbetuximab plus CAPOX in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: the randomized, phase 3 GLOW trial”的研究論文，該研究報(bào)道了佐妥昔單抗(一種靶向CLDN18.2的單克隆抗體)聯(lián)合卡培他濱和奧沙利鉑(CAPOX)作為CLDN18.2陽(yáng)性、HER2陰性、局部晚期不可切除或mG/GEJ腺癌的一線治療。
