GetTopicDetailResponse(id=0d7e9559e44, topicName=酸性微環(huán)境, introduction=酸性微環(huán)境, content=null, image=null, comments=2, allHits=1577, url=https://h5.medsci.cn/topic?id=95597, type=0, isShow=1, status=1, isAdmin=null, adminId=1, adminEncryptionId=1eae1, adminName=小M, createdBy=null, createdName=, createdAvatar=, createdTime=Fri May 29 21:19:53 CST 2020, time=2020-05-29, bannerImg=https://img.medsci.cn/202167/1623032167418_5160405.png, bannerImgH5=https://img.medsci.cn/202167/1623032167418_5160405.png, likes=0, followStatus=false, moduleDTOList=null, tagId=6836, tagList=[TagDto(tagId=6836, tagName=酸性微環(huán)境)], ipAttribution=, topicAdmin=1, lengthMark=0)
[GetTopicListResponse(id=2274314, encodeId=6afa22e4314fb, content=<a href='/topic/show?id=53c66e0011b' target=_blank style='color:#2F92EE;'>#炎癥#</a> <a href='/topic/show?id=430750648d8' target=_blank style='color:#2F92EE;'>#微環(huán)境#</a> <a href='/topic/show?id=0d7e9559e44' target=_blank style='color:#2F92EE;'>#酸性微環(huán)境#</a>, objectTitle=Cell：酸性組織微環(huán)境可能是慢性炎癥的重要肇事者, objectType=article, longId=887791, objectId=362988e791b2, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/images/20250702/9a4dc5fbd5ad4759968215c1a90b2e56-XtOB0kylTXlV.jpg, objectUrl=/article/show_article.do?id=362988e791b2, replyNumber=0, likeNumber=41, createdTime=2025-07-22, rootId=0, userName=梅斯管理員, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=威斯康星, moduleDTOList=[ModuleDTO(moduleId=362988e791b2, moduleTitle=Cell：酸性組織微環(huán)境可能是慢性炎癥的重要肇事者, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=362988e791b2)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2121877, encodeId=b87d21218e79f, content=LDHA 和 LDHB 的表達(dá)水平在多種癌癥類型中升高，例如<a href='/topic/show?id=f9e2832202f' target=_blank style='color:#2F92EE;'>#胃癌#</a>、<a href='/topic/show?id=384b8220449' target=_blank style='color:#2F92EE;'>#肺癌#</a>、<a href='/topic/show?id=73c423e2572' target=_blank style='color:#2F92EE;'>#乳腺癌#</a>、<a href='/topic/show?id=493ae869206' target=_blank style='color:#2F92EE;'>#結(jié)直腸癌#</a>、<a href='/topic/show?id=942b4516096' target=_blank style='color:#2F92EE;'>#子宮內(nèi)膜癌#</a>和<a href='/topic/show?id=04b5839e6a9' target=_blank style='color:#2F92EE;'>#胰腺癌#</a>。升高的 LDHA 和 LDHB 水平與<a href='/topic/show?id=d8dbe130197' target=_blank style='color:#2F92EE;'>#癌癥#</a>患者的不良預(yù)后有關(guān)。因此，<a href='/topic/show?id=2f9c10e5635' target=_blank style='color:#2F92EE;'>#LDH#</a>（以下簡稱 LDHA 和 LDHB）已被公認(rèn)為一種有前途的抗癌藥物<a href='/topic/show?id=07a69996557' target=_blank style='color:#2F92EE;'>#靶點#</a>。選擇 VHL hijack（劫持）E3連接酶，而不是 cereblon (CRBN)，主要是為了避免 CRBN 新底物降解引起的潛在并發(fā)癥。
可以這樣說，<a href='/topic/show?id=0f6b2381e13' target=_blank style='color:#2F92EE;'>#乳酸脫氫酶#</a>，可能是實體瘤的通用靶點，乳酸脫氫酶 <a href='/topic/show?id=c6f814e5136' target=_blank style='color:#2F92EE;'>#PROTAC#</a> <a href='/topic/show?id=f259105e132a' target=_blank style='color:#2F92EE;'>#蛋白降解劑#</a>能夠極大改善腫瘤內(nèi)部的<a href='/topic/show?id=430750648d8' target=_blank style='color:#2F92EE;'>#微環(huán)境#</a>，尤其是<a href='/topic/show?id=0d7e9559e44' target=_blank style='color:#2F92EE;'>#酸性微環(huán)境#</a>，從而讓<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#腫瘤#</a>的<a href='/topic/show?id=ba2b2549371' target=_blank style='color:#2F92EE;'>#代謝重編程#</a>，即<a href='/topic/show?id=91eb2540054' target=_blank style='color:#2F92EE;'>#代謝#</a>逆轉(zhuǎn)為正常細(xì)胞代謝，從而讓腫瘤的惡性度減輕，這是極有希望的一種治療策略。, objectTitle=JMC：發(fā)現(xiàn)第一個乳酸脫氫酶 PROTAC 降解劑有望用于胰腺癌治療, objectType=article, longId=753824, objectId=0b45e5382460, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/images/20221123/dd62c20f18e04055bc5380cacc08dede.jpg, objectUrl=/article/show_article.do?id=0b45e5382460, replyNumber=0, likeNumber=238, createdTime=2023-03-26, rootId=0, userName=俠膽醫(yī)心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=0b45e5382460, moduleTitle=JMC：發(fā)現(xiàn)第一個乳酸脫氫酶 PROTAC 降解劑有望用于胰腺癌治療, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=0b45e5382460)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2121878, encodeId=2fba21218e86c, content=<a href='/topic/show?id=0d7e9559e44' target=_blank style='color:#2F92EE;'>#酸性微環(huán)境#</a><a href='/topic/show?id=026382811f6' target=_blank style='color:#2F92EE;'>#腫瘤免疫微環(huán)境#</a>, objectTitle=如何理解腫瘤免疫微環(huán)境的異質(zhì)性？, objectType=article, longId=751226, objectId=3ef7e5122677, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20221109/1668019382192_4754896.png, objectUrl=/article/show_article.do?id=3ef7e5122677, replyNumber=0, likeNumber=141, createdTime=2023-03-26, rootId=0, userName=俠膽醫(yī)心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=3ef7e5122677, moduleTitle=如何理解腫瘤免疫微環(huán)境的異質(zhì)性？, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=3ef7e5122677)], followStatus=false, userIsMember=false, type=1, lengthMark=0)]
梅斯話題小助手
2020-05-29
