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#MMP# 研究顯示,腫瘤相關巨噬細胞(TAMs)通過抑制對腫瘤細胞的免疫反應和上調基質金屬蛋白酶(MMP)在免疫攻擊下的表達來加速腫瘤進展。MMP9可以切割C-X-C基序趨化因子受體3型(CXCR3)的配體,因此在免疫治療過程中可能影響T細胞的轉運和有效的細胞毒性T細胞反應。多項研究顯示,局部-區(qū)域聯(lián)合治療和ICIs可能增加免疫細胞對腫瘤微環(huán)境的浸潤。