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一些細菌可能是延緩或觸發(fā)RA發(fā)生和進展的關(guān)鍵因素，如<a href='/topic/show?id=cd9a1061586a' target=_blank style='color:#2F92EE;'>#發(fā)酵支原體#</a>、<a href='/topic/show?id=f6ce10605eb4' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=f6ce10605eb4' target=_blank style='color:#2F92EE;'>#普雷沃氏菌#</a></a>、<a href='/topic/show?id=f6ce10605eb4' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=f6ce10605eb4' target=_blank style='color:#2F92EE;'>#普雷沃氏菌#</a></a>、<a href='/topic/show?id=3d9310615931' target=_blank style='color:#2F92EE;'>#干酪乳桿菌#</a>、<a href='/topic/show?id=f05310616066' target=_blank style='color:#2F92EE;'>#脆弱擬桿菌#</a>和<a href='/topic/show?id=809d106161ab' target=_blank style='color:#2F92EE;'>#奇異變形桿菌#</a>, objectTitle=Gut | 中國藥科大學(xué)周衛(wèi)/李菁/南京中醫(yī)藥大學(xué)單進軍李永明揭示腸道共生菌可治療類風(fēng)濕關(guān)節(jié)炎, objectType=article, longId=755119, objectId=4450e55119ec, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/doctor-writing-a-medical-recipe-P8LEKCP.jpg, objectUrl=/article/show_article.do?id=4450e55119ec, replyNumber=0, likeNumber=255, createdTime=2023-05-06, rootId=0, userName=俠膽醫(yī)心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=4450e55119ec, moduleTitle=Gut | 中國藥科大學(xué)周衛(wèi)/李菁/南京中醫(yī)藥大學(xué)單進軍李永明揭示腸道共生菌可治療類風(fēng)濕關(guān)節(jié)炎, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=4450e55119ec)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2126649, encodeId=3871212664912, content=關(guān)鍵<a href='/topic/show?id=2a9f81653c5' target=_blank style='color:#2F92EE;'>#腸道共生菌#</a>——<a href='/topic/show?id=ff98105904f2' target=_blank style='color:#2F92EE;'>#解木聚糖擬桿菌#</a>（Bacteroides xylanisolvens）及新型<a href='/topic/show?id=a3d94e350d6' target=_blank style='color:#2F92EE;'>#尼古丁#</a>代謝酶NicX：解木聚糖擬桿菌通過NicX降解腸道尼古丁，有效緩解<a href='/topic/show?id=13c5394250a' target=_blank style='color:#2F92EE;'>#吸煙#</a>加重的<a href='/topic/show?id=04ea125266c' target=_blank style='color:#2F92EE;'>#NASH#</a>。該研究發(fā)現(xiàn)吸煙過程中尼古丁于腸道累積，闡明其對NASH的促進作用及分子機理，揭示腸道共生菌在尼古丁相關(guān)的NASH發(fā)病中的關(guān)鍵保護作用，為吸煙相關(guān)<a href='/topic/show?id=a06a25432dc' target=_blank style='color:#2F92EE;'>#代謝性疾病#</a>的基礎(chǔ)研究與臨床干預(yù)提供了新靶點與新策略。, objectTitle=Nature：可降解尼古丁的腸道菌群，改善吸煙加重的非酒精性脂肪肝炎, objectType=article, longId=744870, objectId=a119e4487051, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/images/20221009/fefc7938027d4e43a9a6e9b0fa3bf4b8.jpg, objectUrl=/article/show_article.do?id=a119e4487051, replyNumber=0, likeNumber=0, createdTime=2023-04-18, rootId=0, userName=俠膽醫(yī)心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=香港, moduleDTOList=[ModuleDTO(moduleId=a119e4487051, moduleTitle=Nature：可降解尼古丁的腸道菌群，改善吸煙加重的非酒精性脂肪肝炎, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=a119e4487051)], followStatus=false, userIsMember=false, type=1, lengthMark=1)]
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2020-05-29
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關(guān)鍵#腸道共生菌#——#解木聚糖擬桿菌#（Bacteroides xylanisolvens）及新型#尼古丁#代謝酶NicX：解木聚糖擬桿菌通過NicX降解腸道尼古丁，有效緩解#吸煙#加重的#NASH#。該研究發(fā)現(xiàn)吸煙過程中尼古丁于腸道累積，闡明其對NASH的促進作用及分子機理，揭示腸道共生菌在尼古丁相關(guān)的NASH發(fā)病中的關(guān)鍵保護作用，為吸煙相關(guān)#代謝性疾病#的基礎(chǔ)研究與臨床干預(yù)提供了新靶點與新策略。
