GetTopicDetailResponse(id=7ba812e35f3, topicName=NF-κB, introduction=NF-κB, content=null, image=null, comments=1, allHits=2530, url=https://h5.medsci.cn/topic?id=12735, type=0, isShow=1, status=1, isAdmin=null, adminId=1, adminEncryptionId=1eae1, adminName=小M, createdBy=null, createdName=, createdAvatar=, createdTime=Fri May 29 21:19:53 CST 2020, time=2020-05-29, bannerImg=https://img.medsci.cn/202167/1623032167418_5160405.png, bannerImgH5=https://img.medsci.cn/202167/1623032167418_5160405.png, likes=0, followStatus=false, moduleDTOList=null, tagId=4750, tagList=[TagDto(tagId=4750, tagName=NF-κB)], ipAttribution=, topicAdmin=1, lengthMark=0)
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moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=5c078e3445c7)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2230455, encodeId=a8a622304556a, content=<a href='/topic/show?id=0cb91634355' target=_blank style='color:#2F92EE;'>#sirt1#</a> <a href='/topic/show?id=7face61750b' target=_blank style='color:#2F92EE;'>#類風(fēng)濕性關(guān)節(jié)炎#</a> <a href='/topic/show?id=7ba812e35f3' target=_blank style='color:#2F92EE;'>#NF-κB#</a> <a href='/topic/show?id=ec9f8982d9' target=_blank style='color:#2F92EE;'>#HMGB1#</a> <a href='/topic/show?id=9b241158209c' target=_blank style='color:#2F92EE;'>#烏頭湯#</a>, objectTitle=J Ethnopharmacol：烏頭湯通過sirt1介導(dǎo)的HMGB1/NF-κB通路去乙?；瘻p輕大鼠類風(fēng)濕關(guān)節(jié)炎, objectType=article, longId=846661, objectId=bf8284666166, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/202401008/1728353570247_8538692.png, objectUrl=/article/show_article.do?id=bf8284666166, replyNumber=0, likeNumber=139, createdTime=2024-10-12, rootId=0, userName=梅斯管理員, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=bf8284666166, moduleTitle=J Ethnopharmacol：烏頭湯通過sirt1介導(dǎo)的HMGB1/NF-κB通路去乙?；瘻p輕大鼠類風(fēng)濕關(guān)節(jié)炎, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=bf8284666166)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2191012, encodeId=8ea921910121a, content=<a href='/topic/show?id=f5885086f1' target=_blank style='color:#2F92EE;'>#COPD#</a> <a href='/topic/show?id=ecfa1423117' target=_blank style='color:#2F92EE;'>#PI3K#</a> <a href='/topic/show?id=7ba812e35f3' target=_blank style='color:#2F92EE;'>#NF-κB#</a> <a href='/topic/show?id=7ee51303e38' target=_blank style='color:#2F92EE;'>#Nrf2#</a> <a href='/topic/show?id=e1cf82352c7' target=_blank style='color:#2F92EE;'>#肺部炎癥#</a> <a href='/topic/show?id=755011190e49' target=_blank 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href='/topic/show?id=3ed881343fa' target=_blank style='color:#2F92EE;'>#肝纖維化#</a>的機(jī)制的，這是臨床上常見的現(xiàn)象，但是機(jī)制并不清楚。過去認(rèn)為可能是<a href='/topic/show?id=8c2120038ff' target=_blank style='color:#2F92EE;'>#上皮間質(zhì)化#</a>（EMT）導(dǎo)致的，當(dāng)然炎癥信號(hào)通路肯定起關(guān)鍵作用，因此，<a href='/topic/show?id=7ba812e35f3' target=_blank style='color:#2F92EE;'>#NF-κB#</a>途徑是必然參與其中的，其它信號(hào)如TGF-beta, SMAD3等都會(huì)參與其中的。同時(shí)，肝纖維化和<a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'>#肝癌#</a>時(shí)，<a href='/topic/show?id=4a0281923d' target=_blank style='color:#2F92EE;'>#GP73#</a>水平上升，它是<a href='/topic/show?id=36a8102336cb' target=_blank style='color:#2F92EE;'>#高爾基體#</a>上的重要蛋白，因此，將它們關(guān)聯(lián)起來，確實(shí)是一個(gè)比較巧妙的構(gòu)思！青年基金能想到這樣，相當(dāng)不錯(cuò)。, objectTitle=膽汁酸通過激活NF-κB途徑及破壞高爾基體結(jié)構(gòu)上調(diào)肝纖維化/肝硬化患者血清GP73水平的機(jī)制研究, objectType=nsfc, longId=905737, objectId=0318905e375e, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/sci/nsfc_show.do?id=0318905e375e, 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2020-05-29
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這個(gè)課題本來是解釋：#膽汁酸#誘導(dǎo)#肝纖維化#的機(jī)制的，這是臨床上常見的現(xiàn)象，但是機(jī)制并不清楚。過去認(rèn)為可能是#上皮間質(zhì)化#（EMT）導(dǎo)致的，當(dāng)然炎癥信號(hào)通路肯定起關(guān)鍵作用，因此，#NF-κB#途徑是必然參與其中的，其它信號(hào)如TGF-beta, SMAD3等都會(huì)參與其中的。同時(shí)，肝纖維化和#肝癌#時(shí)，#GP73#水平上升，它是#高爾基體#上的重要蛋白，因此，將它們關(guān)聯(lián)起來，確實(shí)是一個(gè)比較巧妙的構(gòu)思！青年基金能想到這樣，相當(dāng)不錯(cuò)。
