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#肝癌# #炎癥微環(huán)境# 由多種免疫細(xì)胞、非血源性間質(zhì)細(xì)胞、以及多種#炎性# 介質(zhì)組成。肝癌進(jìn)展過程中，免疫抑制因素占據(jù)優(yōu)勢，削弱抗腫瘤免疫。因此，深入探討肝癌的免疫調(diào)節(jié)機(jī)制，有助于開發(fā)肝癌的免疫治療新策略。Chemerin是一個新發(fā)現(xiàn)的炎癥相關(guān)蛋白，文獻(xiàn)報道和我們的研究揭示chemein通過多種機(jī)制調(diào)節(jié)炎癥。
Chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), tazarotene-induced gene 2 protein (TIG2), or RAR-responsive protein TIG2 is a protein that in humans is encoded by the RARRES2 gene，Chemerin has been implicated in autocrine / paracrine signaling for adipocyte differentiation and also stimulation of lipolysis。chemein主要在#肥胖# #糖尿病# 中起關(guān)鍵作用，與腫瘤并不密切??！但是，確實可能影響到#腫瘤微環(huán)境# ，也許是#非酒精性脂肪肝# 向#肝癌# 發(fā)展的重要趨動因素之一，有興趣的朋友可以順著我的方向進(jìn)行研究。
