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[GetTopicListResponse(id=2121507, encodeId=b573212150e59, content=<a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'>#肝癌#</a></a><a href='/topic/show?id=28706e01632' target=_blank style='color:#2F92EE;'>#炎癥微環(huán)境#</a>由多種免疫細胞、非血源性間質(zhì)細胞、以及多種<a href='/topic/show?id=a13466968af' target=_blank style='color:#2F92EE;'>#炎性#</a>介質(zhì)組成。肝癌進展過程中，免疫抑制因素占據(jù)優(yōu)勢，削弱抗腫瘤免疫。因此，深入探討肝癌的免疫調(diào)節(jié)機制，有助于開發(fā)肝癌的免疫治療新策略。Chemerin是一個新發(fā)現(xiàn)的炎癥相關(guān)蛋白，文獻報道和我們的研究揭示chemein通過多種機制調(diào)節(jié)炎癥。
Chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), tazarotene-induced gene 2 protein (TIG2), or RAR-responsive protein TIG2 is a protein that in humans is encoded by the RARRES2 gene，Chemerin has been implicated in autocrine / paracrine signaling for adipocyte differentiation and also stimulation of lipolysis。chemein主要在<a href='/topic/show?id=3ad9818917c' target=_blank style='color:#2F92EE;'>#肥胖#</a><a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>中起關(guān)鍵作用，與腫瘤并不密切！！但是，確實可能影響到<a href='/topic/show?id=f0838291817' target=_blank style='color:#2F92EE;'>#腫瘤微環(huán)境#</a>，也許是<a href='/topic/show?id=85d999e268a' target=_blank style='color:#2F92EE;'>#非酒精性脂肪肝#</a>向<a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'><a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'>#肝癌#</a></a>發(fā)展的重要趨動因素之一，有興趣的朋友可以順著我的方向進行研究。, objectTitle=Chemerin抑制肝癌及調(diào)控肝癌炎癥微環(huán)境的機制研究, objectType=nsfc, longId=385512, objectId=1dbe385512b8, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/sci/nsfc_show.do?id=1dbe385512b8, replyNumber=0, likeNumber=312, createdTime=2023-03-24, rootId=0, userName=俠膽醫(yī)心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=1dbe385512b8, moduleTitle=Chemerin抑制肝癌及調(diào)控肝癌炎癥微環(huán)境的機制研究, moduleType=nsfc, hrefUrl=http://ermita.cn/sci/nsfc_show.do?id=1dbe385512b8)], followStatus=false, userIsMember=false, type=1, lengthMark=1)]
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#肝癌# #炎癥微環(huán)境# 由多種免疫細胞、非血源性間質(zhì)細胞、以及多種#炎性# 介質(zhì)組成。肝癌進展過程中，免疫抑制因素占據(jù)優(yōu)勢，削弱抗腫瘤免疫。因此，深入探討肝癌的免疫調(diào)節(jié)機制，有助于開發(fā)肝癌的免疫治療新策略。Chemerin是一個新發(fā)現(xiàn)的炎癥相關(guān)蛋白，文獻報道和我們的研究揭示chemein通過多種機制調(diào)節(jié)炎癥。
Chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), tazarotene-induced gene 2 protein (TIG2), or RAR-responsive protein TIG2 is a protein that in humans is encoded by the RARRES2 gene，Chemerin has been implicated in autocrine / paracrine signaling for adipocyte differentiation and also stimulation of lipolysis。chemein主要在#肥胖# #糖尿病# 中起關(guān)鍵作用，與腫瘤并不密切??！但是，確實可能影響到#腫瘤微環(huán)境# ，也許是#非酒精性脂肪肝# 向#肝癌# 發(fā)展的重要趨動因素之一，有興趣的朋友可以順著我的方向進行研究。
