GetTopicDetailResponse(id=ce7b516e258, topicName=心臟衰老, introduction=心臟衰老, content=null, image=null, comments=1, allHits=1514, url=https://h5.medsci.cn/topic?id=51672, type=0, isShow=1, status=1, isAdmin=null, adminId=1, adminEncryptionId=1eae1, adminName=小M, createdBy=null, createdName=, createdAvatar=, createdTime=Fri May 29 21:19:53 CST 2020, time=2020-05-29, bannerImg=https://img.medsci.cn/202167/1623032167418_5160405.png, bannerImgH5=https://img.medsci.cn/202167/1623032167418_5160405.png, likes=0, followStatus=false, moduleDTOList=null, tagId=77197, tagList=[TagDto(tagId=77197, tagName=心臟衰老)], ipAttribution=, topicAdmin=1, lengthMark=0)
[GetTopicListResponse(id=2263093, encodeId=44c422630930d, content=<a href='/topic/show?id=86ab41e960f' target=_blank style='color:#2F92EE;'>#基因療法#</a> <a href='/topic/show?id=ce7b516e258' target=_blank style='color:#2F92EE;'>#心臟衰老#</a>, objectTitle=Nat Cardiovasc Res 張維綺/曲靜/劉光慧/姚艷開發(fā)延緩心臟衰老的基因療法, objectType=article, longId=873878, objectId=97b18e387853, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20230326/1679867400573_4754896.png, objectUrl=/article/show_article.do?id=97b18e387853, replyNumber=0, likeNumber=39, createdTime=2025-05-01, rootId=0, userName=梅斯管理員, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=陜西省, moduleDTOList=[ModuleDTO(moduleId=97b18e387853, moduleTitle=Nat Cardiovasc Res 張維綺/曲靜/劉光慧/姚艷開發(fā)延緩心臟衰老的基因療法, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=97b18e387853)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2261908, encodeId=993922619082e, content=<a href='/topic/show?id=ce7b516e258' target=_blank style='color:#2F92EE;'>#心臟衰老#</a> <a href='/topic/show?id=30db1263309c' target=_blank style='color:#2F92EE;'>#線粒體通訊#</a>, objectTitle=Cell Death Differ 重慶醫(yī)科大學段晨陽團隊揭示年齡相關的“線粒體通訊障礙”驅動心臟老化, objectType=article, longId=873362, objectId=d8388e3362c1, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20250213/1739441158005_8538692.png, objectUrl=/article/show_article.do?id=d8388e3362c1, replyNumber=0, likeNumber=36, createdTime=2025-04-24, rootId=0, userName=梅斯管理員, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=陜西省, moduleDTOList=[ModuleDTO(moduleId=d8388e3362c1, moduleTitle=Cell Death Differ 重慶醫(yī)科大學段晨陽團隊揭示年齡相關的“線粒體通訊障礙”驅動心臟老化, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=d8388e3362c1)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2161472, encodeId=ac1e21614e248, content=劉光慧/張維綺/曲靜課題組合作發(fā)展逆轉心臟衰老的基因干預策略，<a href='/topic/show?id=62191634516' target=_blank style='color:#2F92EE;'>#SIRT2#</a>-<a href='/topic/show?id=684f16e52c8' target=_blank style='color:#2F92EE;'>#STAT3#</a>-CDKN2B通路在靈長類<a href='/topic/show?id=2e5b51313e0' target=_blank style='color:#2F92EE;'>#心肌細胞#</a><a href='/topic/show?id=4c239032154' target=_blank style='color:#2F92EE;'>#衰老#</a>中的關鍵作用，揭示了可逆轉<a href='/topic/show?id=ce7b516e258' target=_blank style='color:#2F92EE;'>#心臟衰老#</a>的“乙?；_關”。
不過<a href='/topic/show?id=662710682107' target=_blank style='color:#2F92EE;'>#SIRT2家族#</a>一直是衰老領域研究熱點，但是針對<a href='/topic/show?id=4a681068221b' target=_blank style='color:#2F92EE;'>#SIRTs家族#</a>的藥物開發(fā)是失敗的，表明衰老并不是一兩個基因這么簡單。也許SIRTs基因信號只是結果，并非原因。雖然人為強制通過基因編輯干預了信號，可能讓心臟衰老被逆轉，但是同樣會帶來更多的副作用。
未來還需要找到衰老的始動因素，進行預防，而不是治療，才可能是衰老的真正對策。, objectTitle=Nature Aging封面文章：中國科學院劉光慧/張維綺/曲靜課題組合作發(fā)展逆轉心臟衰老的基因干預策略, objectType=article, longId=791784, objectId=567ae9178419, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20230326/1679867384393_4754896.png, objectUrl=/article/show_article.do?id=567ae9178419, replyNumber=0, likeNumber=171, createdTime=2023-10-08, rootId=0, userName=俠膽醫(yī)心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=567ae9178419, moduleTitle=Nature Aging封面文章：中國科學院劉光慧/張維綺/曲靜課題組合作發(fā)展逆轉心臟衰老的基因干預策略, moduleType=article, hrefUrl=http://ermita.cn/article/show_article.do?id=567ae9178419)], followStatus=false, userIsMember=false, type=1, lengthMark=1)]
梅斯話題小助手
2020-05-29
